PKAc-directed interaction and phosphorylation of Ptc is required for Hh signaling inhibition in Drosophila
نویسندگان
چکیده
منابع مشابه
Rab11 is required for maintenance of cell shape via βPS integrin mediated cell adhesion in Drosophila
In eukaryotes, vesicle trafficking is regulated by the small monomeric GTPases of the Rab protein family. Rab11, (a subfamily of the Ypt/Rab gene family) an evolutionarily conserved, ubiquitously expressed subfamily of small monomeric Rab GTPases, has been implicated in regulating vesicular trafficking through the recycling of endosomal compartment. In an earlier communication, we have shown th...
متن کاملrab11 is required for maintenance of cell shape via βps integrin mediated cell adhesion in drosophila
in eukaryotes, vesicle trafficking is regulated by the small monomeric gtpases of the rab protein family. rab11, (a subfamily of the ypt/rab gene family) an evolutionarily conserved, ubiquitously expressed subfamily of small monomeric rab gtpases, has been implicated in regulating vesicular trafficking through the recycling of endosomal compartment. in an earlier communication, we have shown th...
متن کاملmTORC1-mediated inhibition of 4EBP1 is essential for Hedgehog (HH) signaling and can be targeted to suppress HH-driven medulloblastoma
Department of Developmental Neurobiology and Department of Pathology, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA. Sorbonne Universités, UPMC Univ Paris 06, INSERM, CNRS, Centre de Recherche en Myologie (CRM), GH Pitié Salpêtrière, 47 bld de l'hôpital, Paris 13, France. Department of Pathology, The Johns Hopkins University School of Medicine, Ross Build...
متن کاملThe Extracellular Domain of Smoothened Regulates Ciliary Localization and Is Required for High-Level Hh Signaling
Members of the Hedgehog (Hh) family of secreted proteins function as morphogens to pattern developing tissues and control cell proliferation. The seven-transmembrane domain (7TM) protein Smoothened (Smo) is essential for the activation of all levels of Hh signaling. However, the mechanisms by which Smo differentially activates low- or high-level Hh signaling are not known. Here we show that a n...
متن کاملThe Drosophila DmGluRA is required for social interaction and memory
Metabotropic glutamate receptors (mGluRs) have well-established roles in cognition and social behavior in mammals. Whether or not these roles have been conserved throughout evolution from invertebrate species is less clear. Mammals have eight mGluRs whereas Drosophila has a single DmGluRA, which has both Gi and Gq coupled signaling activity. We have utilized Drosophila to examine the role of Dm...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell Discovery
سال: 2019
ISSN: 2056-5968
DOI: 10.1038/s41421-019-0112-z